You've likely heard of the "Tail of the Dragon", Hwy 129 at Deal's Gap, NC. Well, Smyth County Virginia wants you to know about the "Back of the Dragon", 32 miles on Hwy 16 from Tazewell to Marion. There's an annual event and website to promote it. Here's another "Dragon" website with more rides near Wytheville.
Even if you don't attend the annual event, Hwy 16 is still a great ride. 20 miles east of Boone, NC head north on Hwy 16 toward the town of Marion, VA, then continue north to Tazewell. See the map for the rest of this 200 mile loop that begins and ends at the Blue Ridge Parkway. Here's the link for the map and directions.