Once one of the major runs for moonshiners with revenuers hot on their bumper, the road today boasts some great twisties, wide sweepers and unsurpassed scenery. Mountain vistas, waterfalls and secluded lakes appear around nearly every corner. You can find good food, accommodations of every type and unique shops with unusual antiques and crafts created by mountain artisans.
Moonshiner 28 is a great alternative to other, more crowded twisties. Stretching from US 129 at the Tail of the Dragon at Deals Gap, Moonshiner 28 (see map) winds its way southeast through Franklin and Highlands North Carolina before turning southward into Georgia and South Carolina at Walhalla. There are sections of 28 in North Carolina every bit as twisty as US129, but on 28 the speed limit is 55 much of the route.
There's more info at http://www.moonshiner28.com/ and a 274 miles loop with great photos at http://www.tailofthedragontours.com/OOO_Loop/index.html